Publications
Scientific Journal Articles
2025
Van Westrhenen, R., Young, A. H., Heilbronner, U., Juruena, M., Ingelman‐Sundberg, M., Jukic, M., Kaprio, J., Kas, M. J. H., Moldovan, R., Nöthen, M. M., Philipsen, A., Shomron, N., Van Der Eycken, E., Vieta, E., Schulze, T. G., & the PSY‐PGx Consortium. (2025). PSY ‐ PGx: A new intervention for the implementation of pharmacogenetics in psychiatry. World Psychiatry, 24(1), 141–142. https://doi.org/10.1002/wps.21289
2024
Beunk, L., Nijenhuis, M., Soree, B. et al. Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP2C19 and non-SSRI/non-TCA antidepressants. Eur J Hum Genet 32, 1371–1377 (2024). https://doi.org/10.1038/s41431-024-01648-1.
van Westrhenen, R., Young, A. H., Heilbronner, U., Ingelman-Sundberg, M., Jukic, M., Kaprio, J., Kas, M. J. H., Moldovan, R., Nöthen, M. M., Philipsen, A., Shomron, N., Van der Eycken, E., Vieta, E., Schulze, T. G., and The PSY-PGx Consortium. (in press). PSY-PGx: A new intervention for the implementation of pharmacogenetics in psychiatry. World Psychiatry.Heilbronner, U., &
van Westrhenen, R. (2024). Meta-analyses of pharmacogenetics-guided antidepressant treatment: Reply to milosavljevi et al.. European Neuropsychopharmacology. 85:34. https://doi.org/10.1016/j.euroneuro.2024.05.003.
van Westrhenen, R., & Ingelman-Sundberg, M. (2024). Rare variants and clozapine: Reply. European Neuropsychopharmacology. 84:16-17. https://doi.org/10.1016/j.euroneuro.2024.03.004.
de Brabander, E., Kleine Schaars, C., The PSY-PGx Consortium, and van Westrhenen, R. Influence of CYP2C19 and CYP2D6 on side effects of aripiprazole and risperidone: A systematic review. Journal of Psychiatric Research. https://doi.org/10.1016/j.jpsychires.2024.04.001.
Pelgrim, T. A. D., Philipsen, A., Young, A. H., Juruena, M., Jimenez, E., Vieta, E., Jukic, M., Van der Eycken, E., Heilbronner, U., Moldovan, R., Kas, M. J. H., Jagesar, R. R., Nöthen, M. M., Hoffmann, P., Shomron, N., Kilarski, L. L., van Amelsvoort, T., Campforts, B., The PSY-PGx Consortium, & van Westrhenen, R. (2024). A new intervention for implementation of pharmacogenetics in psychiatry: A description of the PSY-PGx clinical study. Pharmaceuticals, 17(151). https://doi.org/10.3390/ph17020151.
2022
Hulshof, E. C., Deenen, M. J., Nijenhuis, M., Soree, B., de Boer-Veger, N. J., Buunk, A.-M., Houwink E. J. F., Risselada, A., Rongen, G. A. P. J. M., van Schaik, R. H. N., Touw, D. J., van der Weide, J., van Westrhenen, R., Deneer, V. H. M., Guchelaar, H.-J., and Swen J. J. Dutch pharmacogenetics working group (DPWG) guideline for the gene–drug interaction between UGT1A1 and irinotecan. European Journal of Human Genetics. https://doi.org/10.1038/s41431-022-01243-2
2021
Brouwer, J. M. J. L., Nijenhuis, M., Soree, Bianca; Guchelaar, H.-J, Swen, J. J., van Schaik, R. H. N., van der Weide, J., Rongen, G. A. P. J. M., Buunk, A.-M., de Boer-Veger, N. J., Houwink, E. J. F., van Westrhenen, R., Wilffert, B., Deneer, V. H. M., and Mulder, H. (2021). Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs. European Journal of Human Genetics. https://doi.org/10.1038/s41431-021-01004-7
van Westrhenen, R., van Schaik, R. H. N., van Gelder, T., Birkenhager, T. K., Bakker, P. R., Houwink, E. J. F., Bet, P. M., Hoogendijk, W. J. G., and van Weelden-Hulshof, M. J. M. (2021). Policy and Practice Review: A First Guideline on the Use of Pharmacogenetics in Clinical Psychiatric Practice. Frontiers in Pharmacology, 12, 640032. https://doi.org/10.3389/fphar.2021.640032
van Westrhenen, R., and Ingelman-Sundberg, M. (2021). Editorial: From Trial and Error to Individualised Pharmacogenomics-Based Pharmacotherapy in Psychiatry. Frontiers in Pharmacology, 12, 725565. https://doi.org/10.3389/fphar.2021.725565
Conference Contributions
Symposia
2024
Young, A., van Westrhenen, R., Van der Eycken, E., McInnis, M. (2024) Collaboration between Research- and Patient Experts in Psychiatric Research. 26th Annual Conference of the International Society for Bipolar Disorders.
2023
van Westrhenen, R., Schulze, T.G., Heilbronner, U., van der Eycken, and Moldovan, R. (2023) When patients experts meet research experts: pharmacgenetics in psychiatry. 23rd WPA World Congress of Psychiatry.
2022
Rietschel M., Heilbronner, U., Deshpande, S., Goes, F., Moldovan, R., Müller, D., van Westrenen, R. (2022) Using Genetics to make Medication fit like a Glove: Where are we? WPA Thematic Congress: New Horizons in Psychiatric Practice: Creative Ideas and Innovative Interventions.
Presentations
2024
van Westrhenen, R. (2024) Pharmacogenetics in Psychiatry: From National to Global Implementation. Congress Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.
van Westrhenen, R. (2024) Lecture symposium Preventing and Ameliorating Treatment-Resistant Depression: Best Practice and Beyond, Optimising treatment response through pharmacogenetic-informed treatment selection. Congress World Federation for Societies of Biological Psychiatry.
van Westrhenen, R. (2024) Pharmacogenetics of antipsychotics and the genetic passport. National Symposium Schizophrenia organized by Royal Dutch Student Association for Biopharmacy (KNPSV), Someren.
van Westrhenen, R. (2024) Pharmacogenetics in Psychiatry (launch of National Network). National Congress Networkcare and Mental Health, Utrecht.
2022
van Westrhenen, R. (2022) Pharmacogenetics in Psychiatry: Current Status Quo. International Society for Affective Disorders.
Goes, F. and van Westrhenen, R. (2022). Pre-Congress Course: The State of the Art of Psychiatric Genetics & Pharmacogenetics. 22nd World Congress of Psychiatry.
van Westrhenen, R. (2022) Phenotype vs Genotype. 11th Biennial Conference on Signal Detection and Signal Management in Pharmacovigilance. Drug Safety Research Unit.
2021
van Westrhenen, R. (2021) PRESIDENTIAL FORUM - Genetics & Psychiatry: Expectations & achievements. 21st WPA World Congress of Psychiatry Virtual Congress.
van Westrhenen, R. (2021) Pharmacogenomics in Psychiatry – The Global Perspective: A Town Hall Meeting (Discussant). WCPG 2021: Virtual World Congress of Psychiatric Genetics.
Posters
2024
Pelgrim, T. A. D., van Oosten, Y., Heilbronner, U., European College of Neuropsychopharmacology (ECNP) Working Group Pharmacogenomics & Transcriptomics, The PSY PGx Consortium, van Westrhenen, R. (2024). Unravelling the Pharmacogenetic Landscape of Antipsychotic induced heart rate corrected QT interval prolongation: a systematic Review. European Union’s Horizon 2020 research and innovation program.
Ștefan, T., Ciucă, A., Heilbronner, U., Young, A., Schulze, T.G., The PSY-PGx Consortium, Van Westrhenen, R., and Moldovan, R. (2024). Assessment of patient reported outcomes and measures in clinical trials investigating the impact of pharmacogenetic testing in psychiatry. ESHG 2024: European Society of Human Genetics.
Pelgrim, T.A.D., van Oosten, Y., Heilbronner, U., European College of Neuropsychopharmacology (ECNP) Working Group Pharmacogenomics & Transcriptomics, The PSY-PGx Consortium, and van Westrhenen, R. (2024). Pharmacogenetics of antipsychotic induced corrected QT (QTC) interval prolongation: A systematic review. Spring Meeting of the Dutch Society for Clinical Pharmacology & Biopharmacy (NVKFB).
Heilbronner, U., Budde, M. , Young, A.H., Juruena, M., Fares-Otero, N.E., Jiménez, E., Vieta, E., Kas, M.J., Jukic, M., Nöthen, M. Philipsen, A., Kilarski, L.L., Laatsch, J., Kaprio, J., Ingelman Sundberg, M., Rossner, M.J., Wichert, S.P., Moldovan, R., Van der Eycken, E., de Brabander, E., van Amelsvoort, T., Shomron, N., Schulze, T.G., Man King Ng, R., Olisa, N., Pelgrim, T., Kleine Schaars, K., and van Westrhenen, R. (2024). PSY-PGx – A New Intervention for Implementation of Pharmacogenetics in Psychiatry: An Update. WCPG 2024: World Congress of Psychiatric Genetics.
2023
Budde, M., Heilbronner, U., Young, A. H., Juruena, M., Fares-Otero, N. E., Jiménez, E., Vieta, E., Kas, M. J., Jukic, M., Nöthen, M., Philipsen, A., Kilarski, L. L., Kaprio, J., Ingelman-Sundberg, M., Rossner, M. J. Wichert, S. P., Moldovan, R., de Brabander, E., van Amelsvoort, T., Shomron, N., Schulze, T. G., Ng, R. M. K., Olisa, N., Van der Eycken, E., Pelgrim, T., Kleine Schaars, K., and van Westrhenen, R. (2023) PSY-PGx – A New Intervention for Implementation of Pharmacogenetics in Psychiatry: Progress and Challenges. WCPG 2023: World Congress of Psychiatric Genetics.
de Brabander, E., Kleine Schaars, K., van Amelsvoort, T., The PSY-PGx Consortium, and van Westrhenen, R. (2023) Influence of CYP2C19 and CYP2D6 on Side Effects of Aripiprazole and Risperidone: A Systematic Review. ECNP 2023: Congress of the European College of Neuropsychopharmacology.
Kleine Schaars, C. T. M, Pelgrim, T. A. D. , Ingelman-Sundberg, M., Young, A. H., Heilbronner, U., The PSY-PGx Consortium, van Westrhenen, R. (2023) Assessing the importance of gender and age-related influences of CYP enzyme activity; the next step into personalized medicine. ECNP 2023: Congress of the European College of Neuropsychopharmacology.
2021
Heilbronner, U., Young, A. H., Juruena, M., Vieta, E., Jimenez, E., Kas, M. J., Jukic, M., Nöthen, M., Philipsen, A., Kilarski, L., Kaprio, J., Ingelman-Sundberg, M., Rossner, M., Wichert, S., Moldovan, R., Rutten, B., Guloksuz, S., Schruers, K., Shomron, N., Schulze, T. G., Ng, R. M. K., Olisa, N., Van der Eycken, E., Budde, M., van Hell, E., and van Westrhenen, R. (2021) PSY-PGx – A New Intervention for Implementation of Pharmacogenetics in Psychiatry. WCPG 2021: Virtual World Congress of Psychiatric Genetics.
Other
2024
Podcasts
De Nieuws BV. Farmacogenetica: DNA testen in de psychiatrie zijn de toekomst.
Presentations
van Westrhenen, R. (2024) Pharmacogenetics in Psychiatry: from national to global implementation. Invited lecture University Oslo, Norway (31 May)
van Westrhenen, R. (2024) Dutch Patient organisation of people with bipolar disorder lecture Pharmacogenetics in Psychiatry. Webinar Plus Minus.
Workshops
Deshpande, S., & van Westrhenen, R. (2024) Workshop Pharmacogenetics in Psychiatry-a primer workshop. St. John’s Research Institute & St. John’s Medical College Hospital, Bengaluru, India (30-31 Jan 2024) prof. Tony Raj, St. John’s, Bengalure, Prof. Johnson Pradeep, St. John’s Bengaluru (Organiser).
van Westrhenen, R. (2024) Workshop Pharmacogenetics in Psychiatry. Online. Dutch National Congress on Pharmacotherapy in Psychiatry.
Book Chapters
van Westrhenen, R. (2024). Pharmacogenomics and the management of mood disorders. In A. Young, M. Sanches, J. Soares, & M. Juruena (Eds.), Clinical Textbook of Mood Disorders (Chapter 25). Cambridge University Press. https://doi.org/10.1017/9781108973922 (ISBN 9781108973922)
Publications in Journals without Impact Factor
Timmermanns, M. (2024) Medicijnen Op Maat. Trouw. 4-5.
Titre, D. (2024) Farmacogenetica in de Psychiatrie: Patient ervaart minder bijwerkingen. Pharmaceutic Weekblad. 159:36
van Westrhenen, R. (2024). Interview met Roos van Westrhenen. Psyfar, 19(1), March 2024.
2023
Videos
Patient Videos produced by PSY-PGx
Workshops
World Psychiatric Association (van Westrhenen et al.) (2023). Innovations in Treatment & Psychosocial Rehabilitation: How to optimally implement genetics and pharmacogenetics in psychiatry. WPA Thematic Congress in Abu Dhabi, United Arab Emirates.
World Psychiatric Association (van Westrhenen et al.) (2023). Innovations in the Practice of Psychiatry in XXI Century: How to optimally implement genetics and pharmacogenetics in psychiatry: a panel discussion. WPA Regional Congress in Yerevan, Armenia.
Publications in Journals without Impact Factor
Pelgrim, T., & van Westrhenen, R. (2023). Een grootschalig internationaal project naar personaliseren van medicatie in de Psychiatrie. De Jonge Apotheker, 29, 18-19.
van Westrhenen, R. (2023). Algoritme voor medicatie op maat. Ypsylon Nieuws, First Edition 2023.
van Westrhenen, R. (2023). Farmacogenetica in de Psychiatrie. PIL (tijdschrift voor huisartsen en apothekers), 12(2), 40-43.
van Westrhenen, R. (2024). Hoe je eigen DNA medicatie op maat geeft. Vizier (uitgave van de Angst, Dwang en Fobie stichting), 53, 28-30.
2022
Workshops
Kane, E. (2022) Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs, Brouwer et al. Journal Club - The Maudsley Training Programme, King's College London.
van Westrhenen, R. (2022) Pharmacogenetics in Psychiatry. Journal Club - The Maudsley Training Programme, King's College London.
2021
Workshops
van Westrhenen, R. (2021) Implementation of Pharmacogenetics in Psychiatry. UMC Utrecht Clinical Trial Center webinar: latest developments in psychosis research.