Summary

PSY-PGx will develop a new personalized approach for clinical medication prescription in psychiatry by:

Assessing data from the FinnGen Research Project and the UK Biobank for the relationship between pharmacogenetic data and clinical outcome in psychiatric patients. A first medication prescription algorithm will be set-up based on machine learning approaches.
Performing a Clinical Study comparing individualized medication prescription based on pharmacogenetics in psychiatric patients to treatment as usual (i.e. in trial-and-error ways), with patient assessed recovery as primary endpoint (RAS: recovery assessment scale). Its outcome will be analyzed and added to already available dosing guidelines.
Collecting individual patient characteristics during the Clinical Study to identify additional factors that influence individual medication response by deeply phenotyping patients including passive monitoring for behavioral aspects.
Applying machine learning to further develop the medication prescription algorithm (that was developed in step 1) to personalize treatment in psychiatry.
Setting up a PSY-PGx DNA biobank and a cellular biobank to allow for future pharmacogenetic research infrastructure.

PSY-PGx